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KMID : 0861020090240030153
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Korea Journal of Herbology
2009 Volume.24 No. 3 p.153 ~ p.160
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Inhibitory Effect of Extract of Trogopterorum Faeces on the Production of Inflammatory Mediaters
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Kim Byung-Jin
Ham Kyung-Wan
Park Kyung-Bae
Kim Dae-Hyeon
Jo Beom-Yeon
Jo Chang-Rae
Cho Gil-Hwan
Bae Gi-Sang
Park Kyoung-Chel
Koo Bon-Soon
Kim Min-Sun
Song Ho-Joon
Park Sung-Joo
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Abstract
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Objectives : The purpose of this study was to investigate the anti-inflammatory effects of extract from Trogopterorum Faeces (TF) on the RAW 264.7 cells.
Methods : To prove the TF’s anti-inflammatory effects, we investigated nitric oxide (NO) production and own cell viability. We examined the cytokine productions on lipopolysacchride (LPS)-induced RAW 264.7 cells and also cellular regulatory mechanisms.
Results : TF does not have any cytotoxic effect. TF reduced LPS-induced NO production, interleukin (IL)-1b, IL-6, IL-10 and tumor necrosis factor-a (TNF-a) in RAW 264.7 cells. TF inhibited the activation of mitogen-activated protein kinases (MAPKs) such as p38, extracelluar signal-regulated kinase (ERK 1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of inhibitory kappa B a (Ik-Ba) in the LPS-stimulated RAW 264.7 cells. TF reduced the serum levels of IL-1b, IL-6, TNF-a. The survival rate of LPS-induced endotoxin shock was increased by TF administration.
Conclusions : TF down-regulated LPS-induced NO and cytokines production, which could provide a clinical basis for anti-inflammatory properties.
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KEYWORD
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Trogopterorum Faeces (TF), lipopolysaccharide (LPS), inflammation, RAW 264.7 cells, Endotoxin shock
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